Original Article Serum miRNA-203 as a potential biomarker for papillary thyroid carcinoma

Jueru Zheng, Jianjun Li
2016 Int J Clin Exp Med   unpublished
Objective: This study aimed to investigate the potential value of serum miR-203 as noninvasive recurrence -predictive and prognostic biomarker in patients with papillary thyroid carcinoma (PTC). Methods: 165 patients received total thyroidectomy in Ningbo No. 2 Hospital from June, 2008 to September, 2014 were enrolled in this study. Serum expressions of miR-203 were evaluated from the obtained blood samples from all the PTC patients by quantitative real-time PCR. The association between serum
more » ... R-203 expressions with the recurrence and overall survival rate in PTC patients were analyzed. Results: Serum miR-203 expressions were significantly increased in PTC patients with tumor recurrence in comparison with those with no recurrence (P<0.001). ROC analysis suggested that serum miR-203 expression was a significant predicative factor for PTC recurrence with an AUC of 0.755, a sensitivity of 71.1% and a specificity of 80.0% respectively. Results from Kaplan-Meier survival curves showed that high serum miR-203 serum expression was significantly associated with poor overall survival in PTC patients (log-rank P<0.001). The multivariate analysis with Cox regression analysis demonstrated that serum miR-203 expression was an independent prognosis factor for the overall survival rate of PTC patients (HR=6.75, 95% CI: 1.43-15.43, P=0.001). Conclusions: This study demonstrated the potential role of serum miR-203 expression as a non-invasive predicative biomarker for the recurrence and prognosis of PTC.