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An improved algorithm for stoichiometric network analysis: theory and applications

2004
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Computer applications in the biosciences : CABIOS
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Motivation: Genome scale analysis of the metabolic network of a microorganism is a major challenge in bioinformatics. The combinatorial explosion, which occurs during the construction of elementary fluxes (non-redundant pathways) requires sophisticated and efficient algorithms to tackle the problem. Results: Mathematically, the calculation of elementary fluxes amounts to characterizing the space of solutions to a mixed system of linear equalities, given by the stoichiometry matrix, and linear

doi:10.1093/bioinformatics/bti127
pmid:15539452
fatcat:c22tkzq22fayvohphvkjffrijm