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Activation of the hippocampal LXRβ improves sleep-deprived cognitive impairment by inhibiting neuroinflammation
[post]
2021
unpublished
Sleep deprivation (SD) leads to cognitive impairment due to neuroinflammation associated with impaired hippocampal neuronal plasticity and memory processes. Liver X receptors (LXRs), including LXRα and LXRβ isoforms, are crucial for synaptic plasticity as well as anti-inflammation. However, the potential roles of LXRs in the pathogenesis of cognitive impairment induced by SD remain unclear. We revealed that SD resulted in LXRβ reduction in hippocampus, which was associated with upregulated
doi:10.21203/rs.3.rs-435395/v1
fatcat:qsgi5wlopjd4hmkaefu7lqeyue