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# 2005 International Union of Crystallography Printed in Denmark -all rights reserved TLS (translation/libration/screw) models describe rigid-body vibrational motions of arbitrary objects. A single-group TLS model can be used to approximate the vibration of an entire protein molecule within a crystal lattice. More complex TLS models are broadly applicable to describing inter-domain and other internal vibrational modes of proteins. Such models can be derived and refined from crystallographicdoi:10.1107/s0907444905001897 pmid:15809496 fatcat:opz7cztzu5elxkavk6rfeb7laa