EFFECT OF CONTINUOUS AND INTERMITTENT EXERCISE TRAINING PROGRAMS ON PLATELET ACTIVATION AND FIBRINOLYTIC PROFILE OF SEDENTARY MALES

Nur Ruslan, Asok Kumar Ghosh, Adibah Alawiah, Abd Razak, Rosline Hassan, Wan Soriany, Tunku Rahman, Malaysia
2012 International Journal of Basic and Applied Medical Sciences   unpublished
The purpose of this study was to investigate the effectiveness of continuous and intermittent training program on platelet activation and fibrinolytic profiles in healthy sedentary males. 24 healthy sedentary males of 21.8±3.7 years participated in this study. They were divided into 3 groups, like, control group (n=9), continuous training group (n=7) and intermittent training group (n=8). In 12 week training period, the intensities for both the continuous group and intermittent group, for the
more » ... rst 4 weeks, had been kept low as a familiarization trial, but were increased considerably for the next 8 weeks. Platelet activation and fibrinolytic profiles were measured, at the beginning and at the end of training period, by detecting P-selectin and glycoprotein IIb/IIIa. Concentration of the tissue plasminogen activator (t-PA) and concentration of plasminogen activator inhibitor type-1 (PAI-1) antigen were measured as fibrinolytic profiles. O 2 max of each person was evaluated before and after training, following graded exercise protocol till exhaustion. Both the intermittent and continuous type of training did not show any significant change in the gated percentage of CD62p and PAC-1 activation, t-PA and PAI-1 antigen, but improved O 2 max significantly. In conclusion, our study found that 12 weeks of continuous and intermittent training had beneficial effect on O 2 max, but failed to produce any significant variation in fibrinolytic profile and platelet activation variables. This might be due to the fact that a longer training period might be necessary to get the significant variation in coagulation variables rather than the cardio-respiratory variable like, O 2 max.
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