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Maejo Int. J. Sci. Technol
Parasite resistance to antimalarials is a major burden in controlling malaria disease. Genetic mutations within the parasites are found to be the factor in conferring resistance to drugs. In this study, the power of random mutant library and transgenic parasite systems were employed to identify mutations on the antimalarial drug target, viz. Plasmodium falciparum dihydrofolate reductase (DHFR), which could contribute to resistance, and to elucidate the functionality of resistant mutantfatcat:7umu7ry5ajby3l7uxqltaoyjdy