CAPRIN1 is differentially expressed in brain metastatic human breast cancer [post]

Shahan Mamoor
2021 unpublished
Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that cell cycle associated protein 1, encoded by CAPRIN1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary
more » ... ed to primary tumors of the breast. CAPRIN1 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of CAPRIN1 in primary tumors was significantly correlated with patient overall survival. Modulation of CAPRIN1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
doi:10.31219/ fatcat:4xsz6i7hk5b7nghhapzbfnx2ly