Cytotoxicity of clerodane diterpenoids from fresh ripe fruitsof Casearia grewiifolia

Thanesuan Nuanyai, Benjamat Chailap, Anumart Buakeaw, Songchan Puthong
A new clerodane diterpene, Caseargrewiin M (1), and one known compound (2) were isolated from fresh ripe fruits of Casearia grewiifolia. The structures of all isolated compounds were evaluated on the basic 1D ( 1 H and 13 C) and 2D NMR (COSY, HSQC, HMBC and NOESY) spectral data. All compounds were examined cytotoxicity with five human cancer cell lines, Hep-G 2 (hepatocarcinoma), SW620 (colon adenocarcinoma), Chago-K1 (undifferentiated lung carcinoma), KATO-III (gastric carcinoma), and BT474
more » ... east ductal carcinoma). Isolated compounds showed broad cytotoxicity against five human cancer cell lines with IC 50 values between 0.90-6.30 g/mL.
doi:10.14456/sjst-psu.2017.56 fatcat:dojj3pghajc4nja6yal7semo2u