Lactic acid-mediated tandem one-pot synthesis of 2-aminothiazole derivatives: A rapid, scalable, and sustainable process

Mohan Reddy Bodireddy, P.Md. Khaja Mohinuddin, Trivikram Reddy Gundala, N.C. Gangi Reddy, George Weaver
2016 Cogent Chemistry  
Environmentally benign and biodegradable lactic acid is identified as alternative solvent and catalyst for the tandem one-pot synthesis of Hantzsch 2-aminothiazole derivatives (4) from readily available aralkyl ketones (1) through in situ regioselective α-bromination using N-bromosuccinimide (2) followed by heterocyclization using thiourea (3) at 90-100°C. The major advantages of the present method include short reaction times (10-15 min), practical, simple to perform, easy work-up, good yield
more » ... ork-up, good yield of products (up to 96%), productive for large-scale applications, free from apply of α-bromoketones (lachrymator) as substrates, avoids column purification. Hence, the present method meets with the concepts of both Wender's "ideal synthesis" and sustainable chemical process. . His research interests are design and synthesis of medicinally valuable organic compounds and development of catalyst-based synthetic methodologies. He published more than 25 research papers in journals of international repute. He completed two major research projects as principal investigator.
doi:10.1080/23312009.2016.1154237 fatcat:nzty7do4o5dchoy7ep5qedc5be