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Environmentally benign and biodegradable lactic acid is identified as alternative solvent and catalyst for the tandem one-pot synthesis of Hantzsch 2-aminothiazole derivatives (4) from readily available aralkyl ketones (1) through in situ regioselective α-bromination using N-bromosuccinimide (2) followed by heterocyclization using thiourea (3) at 90-100°C. The major advantages of the present method include short reaction times (10-15 min), practical, simple to perform, easy work-up, good yielddoi:10.1080/23312009.2016.1154237 fatcat:nzty7do4o5dchoy7ep5qedc5be