Carotid plaques, but not common carotid intima–media thickness, are independently associated with aortic stiffness

Mahmoud Zureik, Mohammed Temmar, Chris Adamopoulos, Jeanne-Marie Bureau, Dominique Courbon, Frédérique Thomas, Kathryn Bean, Pierre-Jean Touboul, Pierre Ducimetière, Athanase Benetos
2002 Journal of Hypertension  
Objective It has been suggested that non-invasive aortic stiffness measurements can be used as an indicator of atherosclerosis. The relationships of arterial stiffness with arterial wall hypertrophy and atherosclerosis however, have rarely been investigated in large-scale studies. The present study reports the associations of carotid arterial structure assessed by B-mode ultrasound with carotidfemoral pulse-wave velocity in hypertensive and nonhypertensive subjects. Design and methods Free
more » ... d methods Free health examinations were performed on 564 subjects (age 58.2 6 10.8 years, 31.9% of women, 53.2% of all were hypertensive). Carotid± femoral pulse-wave velocity (PWV) was used to assess aortic stiffness. Carotid ultrasound examination included measurements (at sites free of plaques) of intima±media thickness (IMT) at the common carotid arteries (CCA), CCA-lumen diameter, and assessment of atherosclerotic plaques in the extracranial carotid arteries. Results Subjects with carotid plaques had signi®cantly higher mean sex-adjusted values of PWV than those without carotid plaques (12.7 6 0.2 versus 11.1 6 0.1 m/s, P < 0.001). Multivariate analyses showed that this association was independent of sex, age, height, body mass index, mean blood pressure, pulse pressure, diabetes, hypercholesterolaemia and smoking habits (P < 0.009). PWV was positively associated with CCA-IMT and CCA-lumen diameter in sex-adjusted analysis (partial correlation coef®cients (r ) were respectively 0.39 and 0.42, P < 0.001 for each). However, the association of PWV with CCA-IMT, but not that with CCA-lumen diameter, disappeared after further adjustment for age and blood pressure measurements (mean blood pressure and/or pulse pressure). Conclusion This study shows that there is a differential association of PWV with CCA-IMT and carotid plaques. The nature of the independent positive association between atherosclerosis and arterial stiffness should be thoroughly investigated.
doi:10.1097/00004872-200201000-00013 pmid:11791030 fatcat:uy7hra6x7bbt7pvdsasn3hpvcm