HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk

Riobaldo M.R. Cintra, Eliana S. Parra, Natalia B. Panzoldo, Vanessa H.S. Zago, Daniel Z. Scherrer, Jamal Baracat, Edna Nakandakare, Eder C.R. Quintao, Wilson Nadruz, Eliana C. Faria, Andrei C. Sposito
2015 BBA Clinical  
controls (6.3 [2] vs. 3.9 [1.9] ng/mg Cholesterol; p = 0.004). 24S-HC and 27-HC levels were respectively five and 20-fold higher in the arterial tissue of PAD individuals than in those of the controls (p = 0.016 and p = 0.001). Plasma C-reactive protein correlated with plasma 24S-HC (r = 0.51; p = 0.010), 25-HC (r = 0.75; p b 0.001), 27-HC (r = 0.48; p = 0.015), and with tissue 24S-HC (r = 0.40; p = 0.041) and 27-HC (r = 0.46; p = 0.023). Conclusion: The accumulation in the arterial intima of
more » ... ysterols originated enzymatically, and not by the action of free radicals, is associated with the severity of atherosclerotic disease and of the systemic inflammatory activity in individuals with severe PAD.
doi:10.1016/j.bbacli.2015.05.037 fatcat:bmwgb2njzzg5taaz5hl675mq6a