IMPLICATION OF SERUM HOMOCYST EINE LEVEL IN TYPE - 2 DIABETES: A PILOT STUDY
English

Sharique Ahmad, Nasim Akhtar, Saeeda Wasim, Shoaib Irfan
2015 Journal of Evolution of Medical and Dental Sciences  
Increased level of Serum Homocysteine has been found to be responsible for macro and micro vascular complications in Type 2 Diabetes mellitus (T2DM). Homocysteine, a sulfur-containing amino acid, is emerging as an important risk factor for atherosclerosis in patients with end-stage renal disease. This study has been undertaken to observe the serum homocysteine status of the type 2 Diabetics and its co-relations between the glycogenic status and to find out the prevalence of hyperhomocysteinemia
more » ... yperhomocysteinemia in T2DM. The serum homocysteine level of 80 consecutive previously known T2DM patients were measured along with other parameters and the obtained data was analyzed. Mean FPG was 130.30+6.13 mg/dl, mean PPPG was 191.76+10.99 mg/ mean HbA1c was 8.2+2.1 mg/ dl, mean BMl was 25.29+3.88 kg/m 2 and the mean serum homocysteine level was 15.12+6.68, while all 80 subjects were taken together. Considering the normal range for homocysteine as per laboratory standard (15 isu/i), the value could be considered as highest normal. Further, 34% of the patients showed high value i.e. hyperhomocysteinemia, 50% showed highest normal and only 16% showed low normal value. Morever, fasting and the post prandial plasma glucose (PPPG) showed inverse relationship level, which were elevated in 34% of T2DM patients, which indicates the scope for intervention. But the glycolic status was negatively related to the homocysteine level, though the relationship was not statistically significant, which might be due to the small sample size. However, larger population study is needed to validate, furthermore.
doi:10.14260/jemds/2015/1019 fatcat:sdtbyuz7srdyxijzfi3b2krdzy