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Purpose-In order to more precisely differentiate cerebral structures in neuroimaging studies, a novel technique for enhancing the tissue contrast based on a combination of T1-weighetd (T1w) and T2-weighed (T2w) magnetic resonance imaging (MRI) images was developed. Methods-The combined image (CI) was calculated as CI = (T1w−sT2w)/(T1w+sT2w), where sT2w is the scaled T2-weighted image. The scaling factor was calculated to adjust the gray matter voxel intensities in the T2w image so that theirdoi:10.1002/mrm.25560 pmid:25533337 pmcid:PMC4476954 fatcat:xjzzt2kzyzhfrllbl4ktofsg7u