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Entropy-Driven One-Step Formation of Phi29 pRNA 3WJ from Three RNA Fragments
2014
Biochemistry
The emerging field of RNA nanotechnology necessitates creation of functional RNA nanoparticles but has been limited by particle instability. It has been shown that the three-way junction of bacteriophage phi29 motor pRNA has unusual stability and can self-assemble from three fragments with high efficiency. It is generally believed that RNA and DNA folding is energy landscape-dependent, and the folding of RNA is driven by enthalpy. Here we examine the thermodynamic characteristics of the 3WJ
doi:10.1021/bi4017022
pmid:24694349
pmcid:PMC4004221
fatcat:uldq3fvnlfa33aio2h5pmydpye