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A recall-by-genotype study on polymorphisms in the TMPRSS6 gene and oral iron absorption: a study protocol
2019
F1000Research
Oral iron supplementation is commonly used to treat and prevent anaemia. The transmembrane protease serine 6 gene (TMPRSS6), which encodes matriptase 2, is a negative regulator of hepcidin, the key controller of iron homeostasis. Genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) in the TMPRSS6 gene that are associated with an increased risk of iron-deficiency anaemia. We will investigate the in vivo effects of three previously reported TMPRSS6
doi:10.12688/f1000research.19080.1
fatcat:muctqo7s4feyxiljkbvdywiyna