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Computational epitope mapping of class I fusion proteins using Bayes classification
[article]
2022
bioRxiv
pre-print
Antibody epitope mapping of viral proteins plays a vital role in understanding immune system mechanisms of protection. In the case of class I viral fusion proteins, recent advances in cryo-electron microscopy and protein stabilization techniques have highlighted the importance of cryptic or 'alternative' conformations that expose epitopes targeted by potent neutralizing antibodies. Thorough epitope mapping of such metastable conformations is difficult, but is critical for understanding sites of
doi:10.1101/2022.05.23.493016
fatcat:4yg6u25gqvgvvojiq2pgjcuoee