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Toll-like receptors as key mediators in innate antifungal immunity
The Toll protein of Drosophila is a transmembrane receptor involved in dorsoventral polarization during embryonic development and recognition of infection. In mammals, Toll-like receptors (TLRs) constitute a novel protein family involved in innate immunity and respond to a wide spectrum of microorganisms, including fungi, bacteria, viruses, and protozoa. Specific agonists for nine of the ten members of the human TLR family have been described to date. TLRs as well as the TLR-associated adaptordoi:10.1080/13693780400011112 pmid:15682636 fatcat:m7h5mtcyercnxnruacdzpc3r5y