Previously epilepsy was recognized as part of the multiple sclerosis (MS) disease spectrum and treatment with antiepileptic drugs was part of symptomatic MS therapy. These comorbidities in the same patient despite being well known still has not been fully understood. The aim of this study was to evaluate incidence and clinical presentation of epilesy in population of our MS patients. We included in our study 200 patients evaluated in our MS center, 145 females and 55 males. Results: there was

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... statistically significant difference in mean age, disease duration, EDSS score between MS with and MS without epilepsy groups, no differences in clinical presentation of seizures according to the previous immunomodulatory treatment (p>0,05). We found EEG abnormalities in 50% of patients with MS and seizures, in 35% MS patients without seizures, pooled incidence of epilepsy in 3.5% with peak incidence between 4 and 7 years after the onset of multiple sclerosis. There was difference of seizure incidence according to clinical course of MS. The treatment of epilepsy in patients with multiple sclerosis does not requires specific protocols than the general epileptic population, but requires individualized approach in order to achieve the best treatment for both diseases.