In this work, a Lyapunov-based economic model predictive control (LEMPC) method is developed to address economic optimality and closed-loop stability of nonlinear systems using machine learning-based models to make predictions. Specifically, an ensemble of recurrent neural network (RNN) models via a k-fold cross validation is first developed to capture process dynamics in an operating region. Then, the LEMPC using an RNN ensemble is designed to maintain the closed-loop state in a stability

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... n and optimize process economic benefits simultaneously. Parallel computing is employed to improve computational efficiency of real-time implementation of LEMPC with an RNN ensemble. The proposed machine-learning-based LEMPC method is demonstrated using a nonlinear chemical process example.