The effect of rhG-CSF (KRN8601) on childhood neutropenia

Shinsaku IMASHUKU, Masahiro TSUCHIDA, Michiko SASAKI, Yuuji GUNJI, Kouichi ISHIMOTO, Ichiro TSUKIMOTO, Ichiro INANA, Syouichi KOIZUMI, Takaharu MATSUYAMA, Minoru SAKURAI, Yusuke MIYATA, Hajime NAKAMURA (+8 others)
1990 The Japanese Journal of Pediatric Hematology  
The effect of a recombinant human granulocyte colony-stimulating factor (rhG-CSF , KRN 8601) was studied on 23 pediatric cases (17 boys ; median age , 3 yr) comprising 9 Kostmann, 8 chronic benign, 3 hypogamma-globulinemia-associated, 1 glycogen storage disease Ib-associated , and 2 druginduced neutropenic patients. rhG-CSF was administered subcutaneously at doses of 50-300 itg/m2 or intravenously at doses of 100-200 itglm2, over the periods of 1-10 weeks . Twenty (87.0%) of the 23 patients who
more » ... had neutrophil counts less than 500/mm3 before therapy, demonstrated significant increase of neutrophils. Patients with Kostmann-type neutropenia responded poorly compared with patients with chronic benign neutropenia. Twenty (80.0%) of the total 25 cases showed no side effects , while 5 cases showed minor side effects, which included 1 case with skin rash at the injection site , 1 case with vomiting, and 3 cases with transient increase of laboratory data ; no interruption of therapy was necessary. Considering both the neutrophil-increasing effect and safety, rhG-CSF is useful for childhood neutropenia.
doi:10.11412/jjph1987.4.420 fatcat:kelbhewrcjg5lf6l37txvurf6e