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The effect of rhG-CSF (KRN8601) on childhood neutropenia
小児好中球減少症に対するrhG‐CSF(KRN8601)の投与効果

Shinsaku IMASHUKU, Masahiro TSUCHIDA, Michiko SASAKI, Yuuji GUNJI, Kouichi ISHIMOTO, Ichiro TSUKIMOTO, Ichiro INANA, Syouichi KOIZUMI, Takaharu MATSUYAMA, Minoru SAKURAI, Yusuke MIYATA, Hajime NAKAMURA (+8 others)
1990 The Japanese Journal of Pediatric Hematology  

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The effect of a recombinant human granulocyte colony-stimulating factor (rhG-CSF , KRN 8601) was studied on 23 pediatric cases (17 boys ; median age , 3 yr) comprising 9 Kostmann, 8 chronic benign, 3 hypogamma-globulinemia-associated, 1 glycogen storage disease Ib-associated , and 2 druginduced neutropenic patients. rhG-CSF was administered subcutaneously at doses of 50-300 itg/m2 or intravenously at doses of 100-200 itglm2, over the periods of 1-10 weeks . Twenty (87.0%) of the 23 patients who
more » ... had neutrophil counts less than 500/mm3 before therapy, demonstrated significant increase of neutrophils. Patients with Kostmann-type neutropenia responded poorly compared with patients with chronic benign neutropenia. Twenty (80.0%) of the total 25 cases showed no side effects , while 5 cases showed minor side effects, which included 1 case with skin rash at the injection site , 1 case with vomiting, and 3 cases with transient increase of laboratory data ; no interruption of therapy was necessary. Considering both the neutrophil-increasing effect and safety, rhG-CSF is useful for childhood neutropenia.
doi:10.11412/jjph1987.4.420 fatcat:kelbhewrcjg5lf6l37txvurf6e
lang:ja
Citation

Shinsaku IMASHUKU, Masahiro TSUCHIDA, Michiko SASAKI, Yuuji GUNJI, Kouichi ISHIMOTO, Ichiro TSUKIMOTO, Ichiro INANA, Syouichi KOIZUMI, Takaharu MATSUYAMA, Minoru SAKURAI, Yusuke MIYATA, Hajime NAKAMURA, Megumi ODA, Ayako YOKOBAYASHI, Masao KOBAYASHI, Tatsuo SHIMOKAWA, Shigenori HIGUCHI, Kazuhiro UEDA, Yoshiyuki HANAWA, Fumimaro TAKAKU. "The effect of rhG-CSF (KRN8601) on childhood neutropenia." The Japanese Journal of Pediatric Hematology 4.5 (1990) 420-427