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In order to solve the HP model of the protein folding problem, we investigated traditional energy function and pointed out that its discrete property cannot give direction of the next step to the searching point, causing a challenge to optimization algorithms. Therefore, we introduced the simplified energy function into a turn traditional discrete energy function to continuous one. The simplified energy function totals the distance between all pairs of hydrophobic amino acids. To optimize thedoi:10.1155/2013/398141 fatcat:5odcjdb6tbdnhmgswwlh7ofriy