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Pyruvate dehydrogenase is a mitochondrial multienzyme complex that catalyzes the conversion of pyruvate to acetyl-coenzyme A and regulates the entry of carbohydrate into the tricarboxylic acid cycle for oxidation. During exercise, pyruvate dehydrogenase activation in human skeletal muscle is proportional to the relative aerobic power output (percent V O 2 max) and is regulated by increases in Ca 2ϩ , free ADP, and pyruvate concentrations. Figure 4. PDH activation (PDHa) at rest and during thedoi:10.1097/00003677-200204000-00009 pmid:11991544 fatcat:na5hflpqabauvmnldlnyw3qj2y