Regulation of Pyruvate Dehydrogenase (PDH) Activity in Human Skeletal Muscle During Exercise

Lawrence L. Spriet, George J.F. Heigenhauser
2002 Exercise and sport sciences reviews  
Pyruvate dehydrogenase is a mitochondrial multienzyme complex that catalyzes the conversion of pyruvate to acetyl-coenzyme A and regulates the entry of carbohydrate into the tricarboxylic acid cycle for oxidation. During exercise, pyruvate dehydrogenase activation in human skeletal muscle is proportional to the relative aerobic power output (percent V O 2 max) and is regulated by increases in Ca 2ϩ , free ADP, and pyruvate concentrations. Figure 4. PDH activation (PDHa) at rest and during the
more » ... st and during the first bout (open circles) and third bout (closed circles) of maximal isokinetic cycling. Mole fraction represents percentage of the enzyme in the active (a) form. (Reprinted from Parolin, M.L, A. Chesley, M.P. Matsos, L.L. Spriet, N.L. Jones, and G.J.F. Heigenhauser. Regulation of human skeletal muscle phosphorylase and pyruvate dehydrogenase during maximal intermittent exercise.
doi:10.1097/00003677-200204000-00009 pmid:11991544 fatcat:na5hflpqabauvmnldlnyw3qj2y