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Growth-differentiation factor-15 (GDF-15) is a stress-responsive TGF-β-related cytokine that has emerged as a prognostic biomarker in acute coronary syndrome (ACS) trial populations. Its predictive role in stable coronary heart disease (CHD) has never been assessed. Methods and Results: The circulating levels of GDF-15 were measured by immunoradiometric assay in patients with stable angina pectoris (SAP, n=1352) or ACS (n=877) who were followed for a median of 3.6 years. SAP patients presentingdoi:10.1161/circgenetics.108.824870 pmid:20031597 fatcat:he66ue2yajd7pbxzvjinp7m46y