Growth-Differentiation Factor-15 for Risk Stratification in Patients With Stable and Unstable Coronary Heart Disease: Results From the AtheroGene Study

T. Kempf, J.-M. Sinning, A. Quint, C. Bickel, C. Sinning, P. S. Wild, R. Schnabel, E. Lubos, H. J. Rupprecht, T. Munzel, H. Drexler, S. Blankenberg (+1 others)
2009 Circulation: Cardiovascular Genetics  
Growth-differentiation factor-15 (GDF-15) is a stress-responsive TGF-β-related cytokine that has emerged as a prognostic biomarker in acute coronary syndrome (ACS) trial populations. Its predictive role in stable coronary heart disease (CHD) has never been assessed. Methods and Results: The circulating levels of GDF-15 were measured by immunoradiometric assay in patients with stable angina pectoris (SAP, n=1352) or ACS (n=877) who were followed for a median of 3.6 years. SAP patients presenting with normal (
doi:10.1161/circgenetics.108.824870 pmid:20031597 fatcat:he66ue2yajd7pbxzvjinp7m46y