A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf
.
Role of Grb7 Targeting to Focal Contacts and Its Phosphorylation by Focal Adhesion Kinase in Regulation of Cell Migration
2000
Journal of Biological Chemistry
We have previously described Grb7 association with focal adhesion kinase (FAK) and its possible roles in cell migration. In this paper, we investigated the mechanisms by which Grb7 and its association with FAK regulate cell migration. We found that deletion of the Grb7 SH2 domain eliminated partial Grb7 localization to focal contacts and its ability to stimulate cell migration. Replacement of the SH2 domain with the focal adhesion targeting sequence from FAK resulted in the focal contacts
doi:10.1074/jbc.m001997200
pmid:10893408
fatcat:6d7jj53dyngyxobytcnjliylum