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Identification of novel genes associated with dysregulation of B cells in patients with primary Sjögren's syndrome
Arthritis Research & Therapy
The aim of this study was to identify the molecular mechanism of dysregulation of B cell subpopulations of primary Sjögren's syndrome (pSS) at the transcriptome level. We enrolled patients with pSS (n = 6) and healthy controls (HCs) (n = 6) in the discovery cohort using microarray and pSS (n = 14) and HCs (n = 12) in the validation cohort using quantitative PCR (qPCR). Peripheral B cells acquired from these subjects were separated by cell sorting into four subsets: CD38-IgD+ (Bm1), CD38+IgD+doi:10.1186/s13075-020-02248-2 pmid:32571405 fatcat:7qeoebwp2ff4rdhmbz2tg3mkr4