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Ki-67 is a nuclear proliferative marker. It is therefore widely used as a cell proliferation marker to grade tumors. Aim of Study: The aim of the current study was to assess the possible association between Ki-67 and the aggressiveness of hepatocellular carcinoma. Material and Methods: This study was conducted at Pathology Department in National Liver Institute, Menoufia University. A total of 114 cases were included. TMA was performed for tumor blocks and stained with antibody against Ki-67.doi:10.21608/mjcu.2019.53903 fatcat:za4ro5hwdfccnc5zd4wcvq2464