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Copper-Catalyzed Modular Assembly of Polyheterocycles
Easy operation, readily accessible starting materials, and short syntheses of the privileged scaffold indeno[1,2c]isoquinolinone were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia−Ugi-four component reaction (4CR)/copper-catalyzed annulation sequence. The optimization and scope and limitations of this short and general sequence are described. The methodology allows an efficient construction of a wide variety of indenoisoquinolinones in just two steps.doi:10.1021/acs.joc.0c01238.s001 fatcat:fbw32h7zxndkjlmxsohweixzqy