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Ca2+ signaling in astrocytes is sleep-wake state specific and modulates sleep
[article]
2019
bioRxiv
pre-print
Astrocytic Ca2+ signaling has been intensively studied in health and disease but remains uncharacterized in sleep. Here, we employed a novel activity-based algorithm to assess astrocytic Ca2+ signals in the barrel cortex of awake and naturally sleeping mice while monitoring neuronal Ca2+ activity, brain rhythms and behavior. We discovered that Ca2+ signaling in astrocytes exhibits distinct features across the sleep-wake cycle and is reduced in sleep compared to wakefulness. Moreover, an
doi:10.1101/750281
fatcat:pgudksjw4nhi7n3cz5qormzgbm