Possible Neoangiogenesis in Achilles Tendon Xanthoma with Familial Hypercholesterolemia: A Novel Approach to Achilles Tendon Xanthoma

Tetsu Tanaka, Kazuyuki Yahagi, Osamu Wada, Kai Ninomiya, Yu Horiuchi, Masahiko Asami, Hitomi Yuzawa, Kota Komiyama, Jun Tanaka, Jiro Aoki, Akitake Suzuki, Kazuho Ishizaki (+1 others)
2021 Internal medicine (Tokyo. 1992)  
Achilles tendon xanthoma (ATX) is one of the typical features of familial hypercholesterolemia (FH). The morphological evaluation of ATX by X-ray radiography is widely recognized; however, the utility of other imaging modalities remains unclear. We herein report two cases of FH in which Doppler ultrasound imaging demonstrated a microvascular flow in ATX that only rarely could be observed in normal Achilles tendons. Neoangiogenesis accompanies chronic inflammation and it may play an important
more » ... lay an important role in the deposition of cholesterol crystals leading to ATX. In addition to the morphological evaluation of ATX, the assessment of neoangiogenesis may therefore be essential for the evaluation of ATX.
doi:10.2169/internalmedicine.7326-21 pmid:34121008 fatcat:z2gtxy264zgmpntcnx33o75ly4