Purpose: The aim of this study is to investigate the effect of statin after endovascular treatment (EVT) or surgical reconstruction for infrainguinal disease in patients on outcomes in patients with critical limb ischemia (CLI). , a retrospective analysis was conducted of data from a multicenter study. 460 patients (66.3% men,163 treated with statin,71.7±10.3 years old) with CLI underwent EVT (223 patients) or surgical reconstruction (237 patients) for de novo infrainguinal lesions. The primary

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... outcome measures were amputation-free survival (AFS) and limb salvage. The secondary outcome measures were overall survival, major adverse cardiovascular events (MACE; all-cause death, myocardial infarction and stroke), major adverse limb events (MALE), major adverse cardiovascular and limb events (MACLE) and surgical conversions. Mean follow-up was 28±21 months. Results: The limb salvage rate at 5 years was significantly higher in the statintreated group (90.1% vs 76.8% P=0.0325).However AFS, overall survival, MACE, MALE, MACLE, surgical conversion at 5 years did not differ significantly between two groups. After correcting all end points with baseline variables, statin was effective for improvement limb salvage (HR, 0.52; 95% CI. 0.27-0.96; adjusted P=0.0314). The others were no significant difference between the groups. Limb salvage rate Conclusions: Statin may improve limb salvage rate after EVT or surgical reconstruction for infrainguinal disease in patients with CLI.