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Requirements for strand transfer between internal regions of heteropolymer templates by human immunodeficiency virus reverse transcriptase
1992
Journal of Virology
We have examined the ability of the reverse transcriptase (RT) from human immunodeficiency virus (HIV) to carry out strand transfer synthesis (i.e., switching of the primer to a new template) from internal regions of natural-sequence RNA. A 142-nucleotide RNA template (donor) primed with a specific 20-nucleotide DNA oligonucleotide was used to initiate synthesis. DNA oligonucleotides with homology to internal regions of the donor were used as acceptors. In this system, HIV RT produced strand
doi:10.1128/jvi.66.11.6370-6378.1992
fatcat:w5ormk6wl5cx5bsv23a4lxsp4y