Association between the retinal vascular network and retinal nerve fiber layer in the elderly: The Montrachet study

Louis Arnould, Martin Guillemin, Alassane Seydou, Pierre-Henry Gabrielle, Abderrahmane Bourredjem, Ryo Kawasaki, Christine Binquet, Alain M. Bron, Catherine Creuzot-Garcher, Ireneusz Grulkowski
2020 PLoS ONE  
To investigate the association between the characteristics of the retinal vascular network in the elderly and retinal nerve fiber layer (RNFL) thickness in a population-based study. We conducted a population-based study, the Montrachet study (Maculopathy Optic Nerve, nuTRition neurovAsCular, and HEarT disease), in participants aged ≥ 75 years. RNFL thickness was assessed with spectral-domain optical coherence tomography (SD-OCT). Analysis of the retinal vascular network was performed by means
more » ... the Singapore "I" Vessel Assessment (SIVA) software based on fundus photography. Data from 970 participants were suitable for analysis. Patients with optic neuropathy were excluded. In multivariable analysis, each standard deviation (SD) decrease in the caliber of the six largest arterioles and veins in zone B and the six largest arterioles and veins in zone C was associated with a decrease in global RNFL thickness (β = -1.62 μm, P = 0.001; β = -2.39 μm, P < 0.001; β = -1.56 μm, P = 0.002; and β = -2.64 μm, P < 0.001, respectively). Our study found that decreased retinal vessels caliber were associated with a decreased RNFL thickness in the elderly without optic neuropathy.
doi:10.1371/journal.pone.0241055 pmid:33085730 fatcat:pkovdvwetre2rdm5crdl62p4me