Gene-gene interaction of BLK, TNFSF4, TRAF1, TNFAIP3, and REL in systemic lupus erythematosus

Xu-jie Zhou, Xiao-lan Lu, Swapan K. Nath, Ji-cheng Lv, Sai-nan Zhu, Hai-zhen Yang, Lian-xiang Qin, Ming-hui Zhao, Yin Su, Nan Shen, Zhan-guo Li, Hong Zhang
2011 Arthritis & Rheumatism  
Objective-Although the number of convincingly established genetic associations with systemic lupus erythematosus (SLE) has increased sharply over the last few years, refinement of these associations is required, and their potential roles in gene-gene interactions need to be further investigated. Recent genome-wide association studies (GWAS) in SLE have produced renewed interest in B cell/T cell responses and the NF-κB signaling pathway. The aim of this study was to search for possible gene-gene
more » ... interactions based on identified single-nucleotide polymorphisms (SNPs), in using an approach based on the role of signaling pathways. Methods-The SNPs in BLK, TNFSF4, TRAF1, TNFAIP3, and REL were replicated in order to evaluate genetic associations with SLE. TaqMan genotyping was conducted in 804 Chinese patients with SLE and 722 matched control subjects. A multiple logistic regression model was used to estimate the multiplicative interaction effect of the SNPs, and additive interactions were analyzed by 2 × 2 factorial designs. Data from a previously published GWAS conducted by the International Consortium on the Genetics of Systemic Lupus Erythematosus were derived for comparison and validation.
doi:10.1002/art.33318 pmid:21905002 pmcid:PMC3994469 fatcat:ols2gilf7fftjg3desoqernv3u