tion of the nucleus has also been noted by Gabbi12 in ex¬ perimental urine intoxication. Daddi13 describes ero¬ sion and loss of sharp contour of the nucleus in experi¬ mentally induced insomnia, but he describes similar changes in chronic cocain poisoning14. The total dis¬ appearance of the nucleus has been noted by Montali15, who produced death in animals by rapid mechanical asphyxiation. It can be noticed that none of these le¬ sions are characteristic of any special pathologic con¬ dition.