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An ATP-Sensitive Cl- Channel Current That Is Activated by Cell Swelling, cAMP, and Glyburide in Insulin-Secreting Cells
1995
Diabetes
Although chloride ions are known to modulate insulin release and islet electrical activity, the mechanism or mechanisms mediating these effects are unclear. However, numerous studies of islet Cl~ fluxes have suggested that Cl~ movements are glucose and sulfonylurea sensitive and are blocked by stilbene-derivative Cl~ channel blockers. We now show for the first time that insulinsecreting cells have a Cl~ channel current, which we term Ici,isiet* 10 , current is activated by hypotonic conditions,
doi:10.2337/diab.44.12.1461
pmid:7589855
fatcat:5xi5kbcii5fijmzektabjigdcy