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Demonstration of different metal ion-induced calcineurin conformations using a monoclonal antibody
1985
Journal of Biological Chemistry
It has been suggested that calcineurin, a calmodulin-stimulated phosphatase, may exist in different metal ion-dependent conformational states (Pallen, C.J., and Wang, J. H. (1984) J. Biol. Chem. 259, 6134-6141). Evidence in favor of this hypothesis comes from studies involving a monoclonal antibody, VA1, which is specific for the small (beta) subunit of calcineurin. This antibody inhibits Ni2+-stimulated but not Mn2+-stimulated phosphatase activity against p-nitrophenyl phosphate and
pmid:2984195
fatcat:hg65qu7z2zds7dgoooagptqogu