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Existing host range mutations constrain further emergence of RNA viruses
RNA viruses are capable of rapid host shifting, typically due to a point mutation that confers expanded host range. As additional point mutations are necessary for further expansions, epistasis among host range mutations can potentially affect the mutational neighborhood and frequency of niche expansion. We mapped the mutational neighborhood of host range expansion using three genotypes of the dsRNA bacteriophage phi6 (wildtype and two isogenic host range mutants) on the novel hostPseudomonasdoi:10.1101/394080 fatcat:xadu24dpqve53oetsiwt6uwfxe