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Insight into the quantitative metrics of chemical exchange saturation transfer (CEST) imaging
2016
Magnetic Resonance in Medicine
Purpose-To evaluate the reliability of four CEST imaging metrics for brain tumors, at varied saturation power levels and magnetic field strengths (3-9.4 T). Methods-A five-pool proton exchange model (free water, semi-solid, amide, amine, and NOErelated protons) was used for the simulations. For the in vivo study, eight glioma-bearing rats were scanned at 4.7 T. The CEST ratio (CESTR), CESTR normalized with the reference value (CESTR nr ), inverse Z-spectrum-based (MTR Rex ), and apparent
doi:10.1002/mrm.26264
pmid:27170222
pmcid:PMC5107181
fatcat:3tw2fmpwv5hajbnlbia3ruauiy