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Spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance in colorectal cancer
2014
OncoTarget
The putative tumor suppressor gene spinophilin has been involved in cancer progression in several types of cancer. In this study, we explored the prognostic value of spinophilin expression in 162 colon adenocarcinoma patients. In addition, we generated stably expressing spinophilin-directed shRNA CRC cell lines and studied the influence of spinophilin expression on cellular phenotypes and molecular interactions. We independently confirmed that low spinophilin expression levels are associated
doi:10.18632/oncotarget.2329
pmid:25261368
pmcid:PMC4226699
fatcat:snke2f4opbanlm6rkvhqwva3bm