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TedSim: temporal dynamics simulation of single cell RNA-sequencing data and cell division history
[article]
2021
bioRxiv
pre-print
Recently, the combined scRNA-seq and CRISPR/Cas9 genome editing technologies have enabled simultaneous readouts of gene expressions and lineage barcodes, which allows for the reconstruction of the cell division tree, and makes it possible to trace the origin of each cell type. Computational methods are emerging to take advantage of the jointly profiled scRNA-seq and lineage barcode data to better reconstruct the cell division history or to infer the cell state trajectories. Here, we present
doi:10.1101/2021.06.21.449283
fatcat:c4fxwzvoxnayzddjkppvbn5xg4