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Nigella sativa (NS) Linn. (Ranunculaceae) oil is used in Northern Nigeria for the treatment of malaria, stomach ulcer, and other inflammatory diseases. The effect of NS (NS) oil on inflammation and the nitric oxide (NO) system was investigated in this study. Chronic inflammation was induced using formaldehyde arthritic model while acute inflammation was produced using carrageenan-induced paw oedema in rats. For the chronic inflammatory model, the animals were divided into four groups of fivefatcat:hkg4gujwqff47p2e2tmbt5yedu