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Hemolytic uremic syndrome (HUS) is a rare disease of microangiopathic hemolytic anemia, thrombocytopenia, and renal impairment. Typical HUS follows a diarrheal illness caused by a verocytotoxin-producing bacterium, commonly Escherichia coli O157:H7, and resolves in most cases without sequelae. 1 Atypical HUS (aHUS) is much less common and has a considerably worse prognosis in terms of both mortality and development of ESRD. 2 Mutations in genes encoding complement regulatory proteins anddoi:10.1681/asn.2008080906 pmid:19092117 fatcat:z4euwxpgpfbbdihksjeudwpo4m