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TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins
TMEM106B is an integral membrane protein of late endosomes and lysosomes involved in neuronal function, its over-expression being associated with familial frontotemporal lobar degeneration, and under-expression linked to hypomyelination. It has also been identified in multiple screens for host proteins required for productive SARS-CoV2 infection. Because standard approaches to understand TMEM106B at the sequence level find no homology to other proteins, it has remained a protein of unknowndoi:10.1101/2021.03.12.435176 fatcat:vq6c3rfpujdtlaymushxnexnwq