To clarify the effects of zinc on bone in 漉 o ,5 − week − 01d Wistar rats corresponding to childhood in humans were devided into 4 groups . Control group was fed on standard − diet and orally administered o 夏 ive on . Experimental groups were fed on low − zinc − , standard − and high − zinc − diet respectively , and orally administered 1α DH − D3 dissolved in olive oil. The experimental period was for 4 weeks . 1α 一 〇H − D , is a synthetic analogue , which seems to be rapidly converted to 1 ,

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... ( OH ) 2D3 in vivo . The tibial metaphyses were observed by TEA4 / . Compared with the controL group . the standard − diet十 VDs group showed increased active osteoblasts and young osteocytes . Gap junctions were more often observed in the high− zinc − diet十 VD , group than those in the standard − diet十 VD3 group . Compared with any other group , the low − zinc − diet 十 VD3 group showed decreased active osteoblasts and young osteQcytes , increased relatively inactive osteob 且 asts and mature osteocytes , and osteoclasts . These results suggested that zinc could enhance the effects of 1 , 25( OH ) ,D , on tibial metaphyses of growing rats . 2 ,下