The diagnostic validity of screening tests and laboratory markers in alcohol use disorders
Alkol Kullanim Bozukluklarinda Tarama Testleri ve Laboratuvar Belirteçlerinin Tanisal Etkinliği

Selami Gül, Yildiz Akvardar, Gültekin Taş, Pinar Tuncel
2005 Turk Psikiyatri Dergisi  
To determine the validity of screening tests and markers suggested in the early detection of alcohol use disorders. Male patients aged 20-65 were recruited from a psychiatry clinic. They had been consuming alcohol at least once a week. They were not drug users and had no other diseases that affected the markers mentioned in this study. According to the DSM-IV diagnostic criteria, the diagnostic validity of screening tests [Michigan Alcoholism Screening Test (MAST), CAGE (Cut down, Annoyed,
more » ... down, Annoyed, Guilty, Eye-opener), Alcohol Use Disorders Identification Test (AUDIT)] and markers [Mean corpuscular volume (MCV), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), carbohydrate-deficient transferrin (CDT)] was investigated in alcohol dependent patients (n=29), alcohol abusers (n=28) and social drinkers (n=28). For the diagnosis of dependence, the sensitivity and specificity of the tests were respectively 69% and 100% for GGT, 41% and 93% for CDT, 100% and 57% for MAST, 97% and 86% for CAGE, and 100% and 75% for AUDIT. For the diagnosis of abuse, the sensitivity and specificity of the tests were respectively 32% and 100% for GGT, 32% and 93% for CDT, 86% and 57% for MAST, 75% and 85.7% for CAGE, and 89% and 75% for AUDIT. The widest area under the ROC curve belonged to GGT as a marker and AUDIT as a screening test. According to the results of this study, the marker that has the highest validity is GGT, while AUDIT and CAGE are the best screening tests.
pmid:15793693 fatcat:c2hd6wkekfdmlfv3upjmzbrauy