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Corticosteroids are the most potent anti-inflammatory agents used to treat chronic inflammatory diseases such as bronchial asthma. However, there are a small number (,5%) of asthmatic patients who do not respond well, or at all, to corticosteroid therapy -the corticosteroidresistant and corticosteroid-dependent patients. Although this phenomenon is relatively uncommon, it poses a difficult therapeutic problem because few alternative therapies are available and these patients account for .50% ofdoi:10.1677/joe.0.1780347 pmid:12967328 fatcat:jukppmddpzeahexznr3ew3qlrm