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A self-assembled leucine polymer sensitizes leukemic stem cells to chemotherapy by inhibiting autophagy in acute myeloid leukemia
Chemotherapy is the primary treatment option for acute myeloid leukemia (AML), but leukemic stem cells (LSCs) can survive chemotherapy for disease recurrence and refractory. Here, we found that AML cells obtained from relapsed patients had increased autophagy levels than de novo AML cells. Furthermore, Doxorubicin (DOX) treatment stimulated autophagy in LSCs by repressing the mTOR pathway, and pharmaceutical inhibition of autophagy rendered chemoresistant LSCs sensitive to DOX treatment indoi:10.3324/haematol.2021.280290 pmid:35295079 fatcat:nclwhcxoqzefbbdt4pwe4l3bhq