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Loss ofFgfr1in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint
Journal of Biological Chemistry
Temporomandibular joint osteoarthritis (TMJ OA) is common degenerative disease with few effective disease-modifying treatments in clinic. Fibroblast growth factor (FGF) signaling is implicated in articular cartilage homeostasis, but the functional roles of FGFR1 in TMJ OA remain largely unknown. In this study, we report that deletion of Fgfr1 in TMJ chondrocytes delayed the TMJ OA progression in age-associated spontaneous OA model and abnormal dental occlusion OA model. Immunohistochemicaldoi:10.1074/jbc.ra118.002293 pmid:29691281 fatcat:oexvhuptfzb5xcakxg7lqrz564