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Establishing gene regulatory networks from Parkinson's disease risk loci
[article]
2021
bioRxiv
pre-print
The latest meta-analysis of genome wide association studies (GWAS) identified 90 independent single nucleotide polymorphisms (SNPs) across 78 genomic regions associated with Parkinson's disease (PD), yet the mechanisms by which these variants influence the development of the disease remains largely elusive. To establish the functional gene regulatory networks associated with PD-SNPs, we utilised an approach combining spatial (chromosomal conformation capture) and functional (expression
doi:10.1101/2021.04.08.439080
fatcat:4v3zir7myraonfrptemi4hthti