Phospholipase C-eta Enzymes as Putative Protein Kinase C and Ca2+ Signalling Components in Neuronal and Neuroendocrine Tissues

Alan J. Stewart, Kevin Morgan, Colin Farquharson, Robert P. Millar
2007 Neuroendocrinology  
Phosphoinositol-specific phospholipase C enzymes (PLCs) are central to inositol lipid signaling pathways, facilitating intracellular Ca 2+ release and protein kinase C activation. A sixth class of Phosphoinositol-specific PLC with a novel domain structure, PLC-eta (PLCη) has recently been discovered in mammals. Recent research, reviewed here, shows that this class consists of two enzymes PLCη1 and PLCη2. Both enzymes hydrolyze phosphatidylinositol 4,5-bisphosphate and are more sensitive to Ca
more » ... e sensitive to Ca 2+ than other PLC isozymes and are likely to mediate G-protein coupled receptor signaling pathways. Both enzymes are expressed in neuron-enriched regions, being abundant in the brain. We demonstrate that they are also expressed in neuroendocrine cell lines. PLCη enzymes therefore represent novel proteins influencing intracellular Ca 2+ dynamics and protein kinase C activation in the brain and neuroendocrine systems.
doi:10.1159/000107795 pmid:17895620 fatcat:b5plgdk3vfhgfkmgahvwazgqhi