A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is
Phosphoinositol-specific phospholipase C enzymes (PLCs) are central to inositol lipid signaling pathways, facilitating intracellular Ca 2+ release and protein kinase C activation. A sixth class of Phosphoinositol-specific PLC with a novel domain structure, PLC-eta (PLCη) has recently been discovered in mammals. Recent research, reviewed here, shows that this class consists of two enzymes PLCη1 and PLCη2. Both enzymes hydrolyze phosphatidylinositol 4,5-bisphosphate and are more sensitive to Cadoi:10.1159/000107795 pmid:17895620 fatcat:b5plgdk3vfhgfkmgahvwazgqhi